FEATURES

FAMILY

DESCRIPTION

Also known as TDRD5_HUMAN, TDRD5, TUDOR3. Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TDRD5

Tudor domain-containing protein 5

TDRD5

Molecular Synopsis