FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHB11_HUMAN, HSD17B11, DHRS8, PAN1B, SDR16C2. Can convert androstan-3-alpha, 17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3, 17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

Also known as DHB11_HUMAN, HSD17B11, DHRS8, PAN1B, SDR16C2. Can convert androstan-3-alpha, 17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen met ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HSD17B11

Estradiol 17-beta-dehydrogenase 11

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

HSD17B11

Structural Ligandability

Domains Chains

Distribution