FEATURES

FAMILY

DESCRIPTION

Also known as RN169_HUMAN, RNF169, KIAA1991. Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNF169

E3 ubiquitin-protein ligase RNF169

RNF169

Molecular Synopsis