FEATURES

FAMILY

DESCRIPTION

Also known as NNRE_HUMAN, NAXE, AIBP, APOA1BP, YJEFN1. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed:23719382). Homodimer (By similarity). Interacts with APOA1 and APOA2.

Also known as NNRE_HUMAN, NAXE, AIBP, APOA1BP, YJEFN1. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hyd ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NAXE

NAD(P)H-hydrate epimerase

NAXE

Molecular Synopsis