FEATURES

FAMILY

DESCRIPTION

Also known as CBPC5_HUMAN, AGBL5, CCP5. Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

AGBL5

Cytosolic carboxypeptidase-like protein 5

AGBL5

Molecular Synopsis