FEATURES

FAMILY

DESCRIPTION

Also known as ABCF1_HUMAN, ABCF1, ABC50. Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. Isoform 2 interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Isoform 2 associates (via both ABC transporter domains) with the ribosomes.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ABCF1

ATP-binding cassette sub-family F member 1

ABCF1

Molecular Synopsis