FEATURES

DESCRIPTION

Also known as REPS2_HUMAN, REPS2, POB1. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). Interacts with EPN1; the interaction is direct (PubMed:10393179, PubMed:10557078). Interacts with EPS15; the interaction is direct (PubMed:10393179). Interacts with EPS15L1 (PubMed:10393179). Interacts with RALBP1; can form a ternary complex with activated Ral (RALA or RALB) (PubMed:9422736). Interacts with ASAP1; the interaction is direct and this complex can bind paxillin (PubMed:12149250). Also forms a ternary complex with RALBP1 and ASAP1 (PubMed:12149250). Interacts with GRB2 (PubMed:9422736).

EXTERNAL LINKS

REPS2

RalBP1-associated Eps domain-containing protein 2

REPS2

Molecular Synopsis