FEATURES

DESCRIPTION

Also known as I17RE_HUMAN, IL17RE. Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. Forms heterodimers with IL17RA; the heterodimer binds IL17C.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IL17RE

Interleukin-17 receptor E

IL17RE

Molecular Synopsis