FEATURES

FAMILY

DESCRIPTION

Also known as NEUA_HUMAN, CMAS. Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Homotetramer; the active enzyme is formed by a dimer of dimers.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CMAS

N-acylneuraminate cytidylyltransferase

CMAS

Molecular Synopsis