FEATURES

DESCRIPTION

Also known as LPD6B_HUMAN, LYPD6B. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LYPD6B

Ly6/PLAUR domain-containing protein 6B

LYPD6B

Molecular Synopsis