FEATURES

DESCRIPTION

Also known as INADL_HUMAN, PATJ, CIPP, INADL. Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). Forms a ternary complex with PALS1, CRB1 and CRB3 (PubMed:11927608, PubMed:11964389). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, INADL/PATJ and PARD3/PAR3 (PubMed:16678097). Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (By similarity). Component of a complex composed of CRB3, PALS1 and PATJ (By similarity). Interacts (via N-terminus) with PALS1/PALS (via PDZ domain) (PubMed:11927608, PubMed:12527193). Interacts with TJP3/ZO-3 and CLDN1/claudin-1 (PubMed:12021270). Interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, HTR2A and SLC6A4 (By similarity). Interacts with MPP7 (PubMed:12021270). Directly interacts with HTR4 (By similarity). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif) (PubMed:18596123). Interacts with SLC6A4 (By similarity). Interacts (via C-terminus) with ARHGEF18 (PubMed:22006950). Interacts with NPHP1 (PubMed:19755384). Interacts with PARD3/PAR3 (By similarity).

Also known as INADL_HUMAN, PATJ, CIPP, INADL. Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required ...

EXTERNAL LINKS

PATJ

Mutations

Mutation(s) distribution

Mutations table