FEATURES

FAMILY

DESCRIPTION

Also known as ISDB_STAAW, isdB, frpB, sasJ, sirH. Cell wall-anchored surface receptor that extracts heme from oxidized methemoglobin/metHb to enable growth on hemoglobin as a sole iron source (PubMed:24871270). Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization. Promotes also resistance to hydrogen peroxide and killing by neutrophils (PubMed:18097052). Interacts with host HBA; this interaction allows heme extraction as iron source. Interacts with IsdA.

EXTERNAL LINKS

uniprot
enzyme classification

isdB

Iron-regulated surface determinant protein B

isdB

Molecular Synopsis