FEATURES

FAMILY

DESCRIPTION

Also known as TRPM8_MOUSE, Trpm8, Ltrpc6, Trpp8. Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Interacts (via N-terminus and C-terminus domains) with TCAF1; the interaction stimulates TRPM8 channel activity. Interacts (via N-terminus and C-terminus domains) with TCAF2; the interaction inhibits TRPM8 channel activity (By similarity). Homotetramer.

Also known as TRPM8_MOUSE, Trpm8, Ltrpc6, Trpp8. Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below ...

EXTERNAL LINKS

Trpm8

Transient receptor potential cation channel subfamily M member 8

Mutations

Mutation(s) distribution

Mutations table

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