FEATURES

FAMILY

DESCRIPTION

Also known as HMGC2_HUMAN, HMGCLL1. Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HMGCLL1

3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

HMGCLL1

Molecular Synopsis