FEATURES

FAMILY

DESCRIPTION

Also known as P4K2B_HUMAN, PI4K2B. Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4, 5-bisphosphate (PIP2), a precursor of the second messenger inositol 1, 4, 5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.

EXTERNAL LINKS

PI4K2B

Phosphatidylinositol 4-kinase type 2-beta

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

PI4K2B

Structural Ligandability

Domains Chains

Distribution