FEATURES

DESCRIPTION

Also known as MARH1_HUMAN, MARCHF1, MARCH1, RNF171. E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.

Also known as MARH1_HUMAN, MARCHF1, MARCH1, RNF171. E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and pro ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MARCHF1

E3 ubiquitin-protein ligase MARCHF1

MARCHF1

Molecular Synopsis