FEATURES

FAMILY

DESCRIPTION

Also known as ACMSD_HUMAN, ACMSD. Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACMSD

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

ACMSD

Molecular Synopsis