FEATURES

FAMILY

DESCRIPTION

Also known as NEK7_HUMAN, NEK7. Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596). Phosphorylates RPS6KB1 (By similarity). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Monomer (PubMed:21320329). Interacts with NEK9 (PubMed:19414596). Interacts with ANKS3; this interaction alters the subcellular distribution of NEK7 by preventing its nuclear translocation (PubMed:26188091).

EXTERNAL LINKS

NEK7

Mutations

Mutation(s) distribution

Mutations table