FEATURES

FAMILY

DESCRIPTION

Also known as DTD1_HUMAN, DTD1, C20orf88, DUEB, HARS2. Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034)., An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. Homodimer (PubMed15653697). Interacts with CDC45 and TOPBP1 (PubMed:20065034).

Also known as DTD1_HUMAN, DTD1, C20orf88, DUEB, HARS2. Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:200650 ...

EXTERNAL LINKS

DTD1

Mutations

Mutation(s) distribution

Mutations table