FEATURES

FAMILY

DESCRIPTION

Also known as LECF_ASPOZ, fleA. Lectin that specifically binds to L-fucose and weakly reacts with mannose and N-acetyl-neuraminic acid (PubMed:12092808). Has strongest preference for the alpha-1, 6-fucosylated chain (core fucose) on glycoproteins among alpha-1, 2-, alpha-1, 3-, alpha-1, 4-, and alpha-1, 6-fucosylated chains (By similarity). Binds to fucose residues of IgE in mice and human, causing antigen-independent IgE-mediated mast cell activation and anaphylactoid reactions in mice and is possibly implicated in allergic response to Aspergillus oryzae in humans (By similarity). Induces secretion of proinflammatory cytokines IL6 and IL8 implicated in ocular diseases such as mycotic keratitis, probably through its interaction with host toll-like receptors TLR2 and TLR4, followed by up-regulation of proinflammatory cytokines (By similarity).

EXTERNAL LINKS

fleA

Fucose-specific lectin

fleA

Molecular Synopsis