FEATURES

FAMILY

DESCRIPTION

Also known as CAST1_HUMAN, CASTOR1, GATSL3. Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Forms homodimers and heterodimers with CASTOR2 (PubMed:26972053, PubMed:27487210). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (PubMed:26972053, PubMed:27487210). Interacts with TM4SF5; the interaction is positively regulated by leucine and is negatively regulated by arginine (PubMed:30956113).

EXTERNAL LINKS

CASTOR1

Mutations

Mutation(s) distribution

Mutations table