FEATURES

FAMILY

rRNA adenine N(6)-methyltransferase family

DESCRIPTION

Also known as TFB1M_HUMAN, TFB1M. S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TFB1M

Dimethyladenosine transferase 1, mitochondrial

TFB1M

Molecular Synopsis