FEATURES

FAMILY

DESCRIPTION

Also known as CANT1_HUMAN, CANT1, SHAPY. Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336). Monomer (PubMed:12234496, PubMed:15006348). Homodimer; dimerization is Ca(2+)-dependent (PubMed:16835225). Homodimer; disulfide-linked (membrane form) (PubMed:16835225).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CANT1

Mutations

Mutation(s) distribution

Mutations table