FEATURES

DESCRIPTION

Also known as PYDC1_HUMAN, PYDC1, ASC2, ASCI, POP1, PYC1. Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. Interacts with PYCARD/ASC (via pyrin domain).

Also known as PYDC1_HUMAN, PYDC1, ASC2, ASCI, POP1, PYC1. Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 a ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PYDC1

Pyrin domain-containing protein 1

PYDC1

Molecular Synopsis