FEATURES

FAMILY

Cation-dependent O-methyltransferase family

DESCRIPTION

Also known as TOMT_HUMAN, LRTOMT, COMT2, TOMT. Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). Interacts with LHFPL5, PCDH15, TMC1, TMC2 and TMIE. Interacts directly with TMC1. The interaction of TOMT with TMC1 and TMC2 is required for the transportation of TMC1/2 into the stereocilia of hair cells.

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EXTERNAL LINKS

LRTOMT

Transmembrane O-methyltransferase

ligandability Mutations

LRTOMT

Molecular Synopsis