FEATURES

DESCRIPTION

Also known as RPGF4_HUMAN, RAPGEF4, CGEF2, EPAC2. Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity). Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A (By similarity).

Also known as RPGF4_HUMAN, RAPGEF4, CGEF2, EPAC2. Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RAPGEF4

Rap guanine nucleotide exchange factor 4

RAPGEF4

Molecular Synopsis