FEATURES

FAMILY

DESCRIPTION

Also known as SOPA_SALTY, sopA. Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Required for inducing polymorphonuclear leukocytes migration across the intestinal epithelium. Preferentially uses host UBE2D1 (UBCH5A), UBE2D2 (UBCH5B) and UBE2L3 (UBCH7) as E2 ubiquitin-conjugating enzymes. Interacts with SpaK/InvB.

EXTERNAL LINKS

uniprot
enzyme classification

sopA

E3 ubiquitin-protein ligase SopA

sopA

Molecular Synopsis