FEATURES

FAMILY

DESCRIPTION

Also known as AK1CL_MOUSE, Akr1c21. NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3, 17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

Akr1c21

Mutations

Mutation(s) distribution

Mutations table