FEATURES

FAMILY

DESCRIPTION

Also known as TWF1_MOUSE, Twf1, Ptk9. Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. Interacts with G-actin; ADP-actin form and capping protein (CP) (PubMed:12807912, PubMed:15282541, PubMed:16511569). May also be able to interact with TWF2 and phosphoinositides, PI(4, 5)P2 (PubMed:12807912). When bound to PI(4, 5)P2, it is down-regulated (PubMed:12807912). Interacts with ACTG1 (By similarity).

EXTERNAL LINKS

Twf1

Mutations

Mutation(s) distribution

Mutations table