FEATURES

FAMILY

DESCRIPTION

Also known as GGH_HUMAN, GGH. Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GGH

Gamma-glutamyl hydrolase

GGH

Molecular Synopsis