FEATURES

FAMILY

DESCRIPTION

Also known as HYAS1_HUMAN, HAS1, HAS. Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HAS1

Hyaluronan synthase 1

HAS1

Molecular Synopsis