FEATURES

FAMILY

DESCRIPTION

Also known as M4K1_HUMAN, MAP4K1, HPK1. Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). Interacts with MAP3K1 (PubMed:8824585). Interacts with FBXW8 (PubMed:24362026). Interacts with CLNK (via its SH2 domain) (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MAP4K1

Mitogen-activated protein kinase kinase kinase kinase 1

MAP4K1

Molecular Synopsis