FEATURES

DESCRIPTION

Also known as LHP1_ARATH, LHP1, TFL2, TU8. Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Transcriptional repressor that binds DNA on GAGA-like motif and 5'-(A/G/T)AACCCTA(A/G)-3' consensus motif in the promoters of target genes. Recognizes and binds histone H3 tails methylated at 'Lys-27' (H3K27me) but depleted in active histone marks such as H3K4me, leading to epigenetic repression. When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes (PubMed:27495811). Homodimer (PubMed:11731464). Interacts with CYP71 (PubMed:21596687). Interacts with histone H3 and CMT3 (PubMed:11898023). Interacts with SUVH (PubMed:15546353). Component of the PRC1-like complex, at least composed of RING1A, RING1B and LHP1 (PubMed:19097900). Binds to POL2A (PubMed:19097900). Interacts with DUF7/AIP1 (PubMed:26538092). Binds to LIF2 in the nucleus on a common set of chromatin regions (PubMed:21304947, PubMed:27495811). Interacts with PDP3, MSI4/FVE and MSI5 (PubMed:29314758). Component of the PRC2 (polycomb repressive complex 2) complex which regulates histone methylation on histone H3K27 (PubMed:29314758).

EXTERNAL LINKS

LHP1

Chromo domain-containing protein LHP1

LHP1

Molecular Synopsis