FEATURES

FAMILY

DESCRIPTION

Also known as UBE2F_HUMAN, UBE2F, NCE2. Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. Interacts with UBA3 and RBX2 (PubMed:19250909). Interacts (N-terminally acetylated form) with (via DCUN1 domain) DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (PubMed:23201271).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UBE2F

NEDD8-conjugating enzyme UBE2F

UBE2F

Molecular Synopsis