FEATURES

FAMILY

Classic translation factor GTPase family

DESCRIPTION

Also known as RRF2M_HUMAN, GFM2, EFG2. Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GFM2

Ribosome-releasing factor 2, mitochondrial

GFM2

Molecular Synopsis