FEATURES

FAMILY

DESCRIPTION

Also known as UB2E3_HUMAN, UBE2E3, UBCE4, UBCH9. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the nucleus. Interacts with NEDD4L.

Also known as UB2E3_HUMAN, UBE2E3, UBCE4, UBCH9. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UBE2E3

Ubiquitin-conjugating enzyme E2 E3

UBE2E3

Molecular Synopsis