FEATURES

FAMILY

DESCRIPTION

Also known as 5NT3B_HUMAN, NT5C3B, NT5C3L. Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NT5C3B

7-methylguanosine phosphate-specific 5'-nucleotidase

NT5C3B

Molecular Synopsis