FEATURES

FAMILY

DESCRIPTION

Also known as F162A_HUMAN, FAM162A, C3orf28, E2IG5. Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity). Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity (PubMed:16698020). Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition (PubMed:15082785).

EXTERNAL LINKS

FAM162A

Protein FAM162A

FAM162A

Molecular Synopsis