FEATURES

FAMILY

DESCRIPTION

Also known as TIP39_HUMAN, PTH2, TIP39, TIPF39. Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Ligand of high affinity for the PTH2 receptor (PTH2R).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTH2

Tuberoinfundibular peptide of 39 residues

Mutations

Mutation(s) distribution

Mutations table

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