FEATURES

FAMILY

cytidine and deoxycytidylate deaminase family

DESCRIPTION

Also known as ABC3D_HUMAN, APOBEC3D, APOBEC3DE. DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. (Microbial infection) Interacts with HIV-1 Vif.

EXTERNAL LINKS

APOBEC3D

DNA dC->dU-editing enzyme APOBEC-3D

APOBEC3D

Molecular Synopsis