FEATURES

FAMILY

DESCRIPTION

Also known as ZUP1_HUMAN, ZUP1, C6orf113, ZUFSP. Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501). Interacts with RPA1 and RPA2.

EXTERNAL LINKS

ZUP1

Zinc finger-containing ubiquitin peptidase 1

ZUP1

Molecular Synopsis