FEATURES

FAMILY

DESCRIPTION

Also known as ARRD3_HUMAN, ARRDC3, KIAA1376. Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). Interacts (via PPxY motifs) with NEDD4 (via WW domains) (PubMed:20559325, PubMed:23208550, PubMed:24379409). Interacts with ADRB2 (PubMed:20559325, PubMed:21982743, PubMed:25220262). Interacts with ADRB3 (PubMed:21982743). Interacts with HGS (via PPxY motifs) (PubMed:23208550). Does not bind TXN (thioredoxin) (PubMed:16269462). Interacts with ITCH (PubMed:23886940). Interacts with WWP1 (via WW domains) (PubMed:21191027).

EXTERNAL LINKS

ARRDC3

Arrestin domain-containing protein 3

ARRDC3

Molecular Synopsis