FEATURES

FAMILY

DESCRIPTION

Also known as DOC10_HUMAN, DOCK10, KIAA0694, ZIZ3. Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DOCK10

Dedicator of cytokinesis protein 10

Mutations

Mutation(s) distribution

Mutations table

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