FEATURES

FAMILY

DESCRIPTION

Also known as NSUN4_HUMAN, NSUN4. Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NSUN4

5-methylcytosine rRNA methyltransferase NSUN4

NSUN4

Molecular Synopsis