FEATURES

FAMILY

DESCRIPTION

Also known as RHES_HUMAN, RASD2, TEM2. GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Monomer (Potential). Interacts with PIK3CA and UBE2I (By similarity). Interacts with GNB1, GNB2 and GNB3. Interacts with HTT; interacts with mutant HTT (mHTT) with a much higher affinity than wild type HTT.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RASD2

GTP-binding protein Rhes

RASD2

Molecular Synopsis