FEATURES

FAMILY

DESCRIPTION

Also known as HDA11_HUMAN, HDAC11. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Interacts with HDAC6.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

HDAC11

Histone deacetylase 11

ligandability Mutations

HDAC11

Molecular Synopsis