FEATURES

FAMILY

DESCRIPTION

Also known as ZDH12_HUMAN, ZDHHC12, ZNF400. Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ZDHHC12

Palmitoyltransferase ZDHHC12

ZDHHC12

Molecular Synopsis