FEATURES

FAMILY

DESCRIPTION

Also known as TONSL_HUMAN, TONSL, IKBR, NFKBIL2. Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2. Interacts with the MCM complex, the FACT complex and the RPA complex. Binds histones. Interacts with histones H3.1 AND H3.1t (PubMed:33857403). May interact with DNAJC9; the interaction seems to be histone-dependent (PubMed:33857403).

Also known as TONSL_HUMAN, TONSL, IKBR, NFKBIL2. Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The ...

EXTERNAL LINKS

TONSL

Tonsoku-like protein

TONSL

Molecular Synopsis