FEATURES

DESCRIPTION

Also known as LRIG1_HUMAN, LRIG1, LIG1. Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. Interacts (via extracellular LRR and Ig-like domains) with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 (via extracellular domain) (PubMed:15282549). The physiological relevance of the interaction is controversial; LRIG1 may have low affinity for EGFR, and interaction may occur only when high levels of both proteins are present (PubMed:25765764).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LRIG1

Leucine-rich repeats and immunoglobulin-like domains protein 1

LRIG1

Molecular Synopsis