FEATURES

FAMILY

N-acetylmuramoyl-L-alanine amidase 2 family

DESCRIPTION

Also known as PGRP4_HUMAN, PGLYRP4, PGRPIB. Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. Homodimer; disulfide-linked. Heterodimer with PGLYRP3; disulfide-linked.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PGLYRP4

Peptidoglycan recognition protein 4

PGLYRP4

Molecular Synopsis